Multiple effects of HMG-CoA reductase inhibitors (statins) besides their lipid-lowering function

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HMG-CoA reductase inhibitors and renal function.

Experimental Evidence for a Role of Dyslipidemia in Renal Injury and for a Renal Protective Effect of Statins T he presence of lipids in renal cells upregulates intracellular signaling pathways involved in inflammatory and fibrogenic responses, both of which are components of progressive renal injury. Lipids activate various growth factors that cause mesangial cell proliferation. Mesangial cell...

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Lipid-lowering drugs and mitochondrial function: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio.

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Pharmacology of the HMG-CoA reductase inhibitors

Pleiotropic effects are now described for the 3-hydroxy-3methylglutaryl-coenzyme A reductase inhibitors (or statins) that might have utility in the context of chronic inflammatory autoimmune disease. Here we discuss the pharmacology and established uses of statins and in this context describe potential anti-inflammatory and immune-modulatory effects. An extensive in vitro data set defines roles...

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Pleiotropic effects of the HMG-CoA reductase inhibitors

The HMG-CoA reductase inhibitors (statins) are used extensively in the treatment of hyperlipidemia. They have also demonstrated a benefit in a variety of other disease processes. These secondary actions are known as pleiotropic effects. Our paper serves as a focused and updated discussion on the pleiotropy of statins and emphasizes the importance of randomized placebo-controlled trials to furth...

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ژورنال

عنوان ژورنال: Kidney International

سال: 2008

ISSN: 0085-2538

DOI: 10.1038/ki.2008.323